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When data were sufficient (that is, obtained from at least 2 randomized, controlled trials) and studies were relatively homogeneous in sample characteristics, study duration, and drug dose, we conducted meta-analyses for the following intermediate outcomes and adverse effects: hemoglobin A 1c level, weight, systolic blood pressure, LDL cholesterol level, HDL cholesterol level, triglyceride level, and hypoglycemia.

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Three years after the study concluded, the majority of patients in each group were receiving a second type of insulin (67.

Few studies of hypoglycemia in people with type 2 diabetes have addressed the potential effects of ageing per se, but the available evidence suggests that it modifies the counterregulatory and symptomatic responses to hypoglycemia.

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Treatment of type 2 diabetes is based on an interplay of patient characteristics, severity of hyperglycemia and available therapeutic options.

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Therefore, while “aspirin resistance” appears higher in the diabetic patients when measured by a variety of ex vivo and in vitro methods (platelet aggrenometry, measurement of thromboxane B 2), these observations alone are insufficient to empirically recommend higher doses of aspirin be used in the diabetic patient at this time.

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Macronutrients, food groups, and eating patterns in the management of diabetes: a systematic review of the literature, 2010.

Where measures of spread for change from baseline values were not reported, the corresponding values at study end were used and were combined with change from baseline values to produce summary estimates of effect.

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Neither drug could produce significant weight loss on its own, but when used together, the effect was golden.

Higher incidence of severe hypoglycemia leading to hospital admission in type 2 diabetic patients treated with long acting versus short acting sulphonylureas.

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Most people with diabetes are recommended to keep their HbA1c levels below 7% to avoid or delay diabetic complications.

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